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Related Experiment Videos

Persistent cognitive dysfunction in patients with obsessive-compulsive disorder: a naturalistic study.

Kyu Sik Roh1, Min Sup Shin, Myung-Sun Kim

  • 1Neuroscience Institute, SNU-MRC, and Department of Psychiatry, Seoul National University, Seoul, Korea.

Psychiatry and Clinical Neurosciences
|October 1, 2005
PubMed
Summary

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Obsessive-compulsive disorder (OCD) patients show persistent cognitive impairments in memory and fluency despite a year of medication. These deficits in visuospatial memory and verbal fluency may be central to OCD pathology.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Obsessive-compulsive disorder (OCD) is associated with cognitive deficits.
  • Understanding the longitudinal course of these cognitive impairments is crucial for treatment.

Purpose of the Study:

  • To investigate the changes in cognitive dysfunctions in patients with OCD over a 1-year period of pharmacological treatment.
  • To compare cognitive performance between OCD patients and normal controls longitudinally.

Main Methods:

  • Neuropsychological tests and clinical evaluations were administered to 21 OCD patients and 20 normal subjects at baseline, 4 months, and 1 year.
  • Specific tests included Rey-Osterrieth complex figure tests, category fluency test, trail making test--part A, and Wisconsin card sorting test.

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Main Results:

  • OCD patients consistently demonstrated significant impairments in visuospatial memory (Rey-Osterrieth recall accuracy).
  • Deficits were also observed in verbal fluency (category fluency responses) and executive functions (Wisconsin card sorting errors).
  • Response times on the trail making test--part A remained slower in OCD patients compared to controls.

Conclusions:

  • Pharmacological treatment over 1 year did not fully resolve cognitive dysfunctions in OCD patients.
  • Impaired visuospatial memory and verbal fluency appear to be core cognitive deficits underlying OCD pathology.