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Updated: Aug 15, 2026

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Coil occlusion for patent ductus arteriosus larger than 3 mm
Toshiyuki Kobayashi1, Hideshi Tomita, Shigeto Fuse
1Department of Pediatrics, Sapporo Medical University School of Medicine, Japan.
Insights
Coil occlusion is a common treatment for patent ductus arteriosus (PDA). This study found adults experienced more hemolysis complications than children after PDA coil occlusion.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- Patent ductus arteriosus (PDA) coil occlusion is a standard first-line treatment.
- Limited data exists on age-related complications of PDA coil occlusion.
Purpose of the Study:
- To investigate age-dependent differences in complications following coil occlusion for patent ductus arteriosus (PDA).
Main Methods:
- Retrospective analysis of 16 patients (11 adults, 5 children) with PDA > 3 mm treated with coil occlusion.
- Evaluation of immediate and intermediate outcomes and complications.
Main Results:
- Procedural success rates were 72.7% in children and 100% in adults.
- Coil migration occurred in 4 children and 1 adult.
- Hemolysis was observed in 3 adult patients, a higher incidence than in children.
Conclusions:
- Hemolysis is a more frequent complication in adults compared to children undergoing PDA coil occlusion, even with trivial residual shunts.
Background:
Coil occlusion of patent ductus arteriosus (PDA) is now widely accepted as the first-line treatment, but there are few reports of age-dependent differences in the complications associated with this technique.
Methods And Results:
Sixteen patients (11 adults, 5 children) with a PDA larger than 3 mm, who underwent coil occlusion at Sapporo Medical University Hospital between September 1995 and August 2004, were enrolled. Immediate and intermediate outcomes and complications were analyzed. Procedural success rate was 72.7% (8/11) in the children and 100% (5/5) in the adults. Coil migration occurred in 4 children and 1 adult, and 3 adult patients had hemolysis.
Conclusion:
Hemolysis was more frequent in adults than in children even though the residual shunt was trivial.

