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Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation
Published on: November 10, 2023
Comparative clinicopathology of obliterative bronchiolitis and diffuse panbronchiolitis
Sakae Homma1, Susumu Sakamoto, Masateru Kawabata
1Department of Respiratory Medicine, Respiratory Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan. sa-homma@toranomon.gr.jp
Respiration; International Review of Thoracic Diseases
|October 1, 2005
Summary
Obliterative bronchiolitis (OB) and diffuse panbronchiolitis (DPB) share clinical symptoms but differ histopathologically. OB lesions are in membranous bronchioli, DPB in respiratory bronchioli, with constrictive OB having a worse prognosis.
Area of Science:
- Pulmonary Medicine
- Pathology
- Respiratory Diseases
Background:
- Obliterative bronchiolitis (OB) causes progressive airway obliteration globally.
- Diffuse panbronchiolitis (DPB) is primarily reported in Japan, suggesting potential overlap with OB in this region.
Purpose of the Study:
- To elucidate the clinicopathological similarities and differences between OB and DPB.
- To compare the histopathological localization of obstructive lesions in OB versus DPB.
Main Methods:
- Clinicopathological evaluation of 15 patients with OB and 6 patients with DPB.
- Analysis of underlying disorders, lung pathology, clinical manifestations, pulmonary function tests, and chest CT images.
Main Results:
- OB lesions primarily affect membranous bronchioli, while DPB lesions are confined to respiratory bronchioli.
- OB presents with underlying conditions like GVHD and rheumatoid arthritis; DPB is associated with chronic parasinusitis.
- Both conditions show obstructive pulmonary impairment; CT scans reveal centrilobular nodules in most cases. Constrictive OB has a poorer prognosis than cellular OB and DPB.
Conclusions:
- Histopathological differences exist between OB and DPB, particularly in the location of obstructive lesions.
- Despite histopathological distinctions, OB and DPB exhibit significant similarities in clinical presentations.
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