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Multiple sclerosis pathology: evolution of pathogenetic concepts.

Hans Lassmann1

  • 1Center for Brain Research, Medical University of Vienna, Spitalgasse 4, A-1090 Wien, Austria. hans.lassmann@meduniwien.ac.at

Brain Pathology (Zurich, Switzerland)
|October 4, 2005
PubMed
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This review traces the history of multiple sclerosis (MS) pathology. Current understanding of MS pathogenesis may be too simple, requiring reevaluation of its fundamental aspects.

Area of Science:

  • Neuropathology
  • Immunology
  • Neurobiology

Background:

  • Early neuropathology defined inflammatory demyelinating lesions in multiple sclerosis (MS).
  • 20th-century immunology and neurobiology advanced understanding of MS molecular mechanisms.

Observation:

  • Descriptive neuropathology laid the foundation for MS research.
  • Immunological and neurobiological advances elucidated inflammatory and destructive processes in MS.

Findings:

  • Historical MS research focused on descriptive neuropathology and later molecular mechanisms.
  • Recent studies suggest current MS pathogenetic concepts are oversimplified.

Implications:

  • Essential aspects of MS pathology require redefinition.

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  • Further research is needed to refine understanding of multiple sclerosis pathogenesis.