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Updated: Aug 15, 2026

Using Three-color Single-molecule FRET to Study the Correlation of Protein Interactions
Published on: January 30, 2018
Fast method for estimating the energy distribution of globular states of proteins
Hai-Bo Cao1, Cai-Zhuang Wang, Kai-Ming Ho
1Department of Physics and Astronomy, Ames Laboratory-U.S. DOE, Iowa State University, Ames, Iowa 50011, USA.
Abstract:
By an enumeration study, we show that the energy distributions of a lattice protein sequence on all possible compact lattice configurations can be approximated by the energy distribution of shuffled sequences on a given lattice structure. We also show that the random energy model (REM) gives a good analytical approximation for the energy distribution of shuffled sequences on lattice structures. For real proteins, when a gapped threading method is used, REM calculations systematically underestimate the mean value of the energy distributions. We found that this discrepancy can be roughly compensated by a linear correction obtained from empirical fits. This result can be used to greatly reduce the computational effort in protein threading calculations.
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