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Proliferative verrucous leukoplakia: an aggressive form of oral leukoplakia
Thomas P Shopper1, Robert B Brannon, William H Stalker
1Department of Oral Diagnosis, Oral Medicine, and Radiology, Louisiana State University School of Dentistry, New Orleans, Louisiana, USA.
Abstract:
Proliferative verrucous leukoplakia (PVL) is an aggressive form of oral leukoplakia that is persistent, often multifocal, and refractory to treatment with a high risk of recurrence and malignant transformation. This article describes the clinical aspects and histologic features of a case that demonstrated the typical behavior pattern in a long-standing, persistent lesion of PVL of the mandibular gingiva and that ultimately developed into squamous cell carcinoma. Prognosis is poor for this seemingly harmless-appearing white lesion of the oral mucosa.
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