[The effect of antiprotein plasma on humoral resistance in children with severe burns]

Area of Science:

• Biochemistry
• Pediatric Medicine
• Trauma Care

Context:

• Severely burned children often develop toxemia and septic toxemia.
• The acute phase of these conditions involves significant physiological changes.
• Monitoring specific blood serum components is crucial for assessing disease severity.

Purpose:

• To investigate alterations in specific blood serum components during toxemia in severely burned children.
• To correlate these biochemical changes with the development and progression of toxic syndromes.
• To evaluate the therapeutic efficacy of donor antiproteic plasma.

Summary:

• In severely burned children, decreased anti-triptic activity, alpha 2-macroglobulin, fibronectin, and arginase activity were observed during acute toxemia and septic toxemia.
• Concurrently, there was a significant increase in fibrin-fibrinogen degradation products.
• These alterations in studied indices are informative regarding the toxic syndrome's dynamics.

Impact:

• The findings highlight key biomarkers for monitoring toxic syndrome in pediatric burn patients.
• Understanding these biochemical shifts aids in predicting disease progression.
• Donor antiproteic plasma demonstrates a beneficial therapeutic effect, suggesting its potential role in managing severe burn complications.