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Nonlinear PI controllers for continuous bioreactors using population balance models.

Wei Wu¹, Haw-Yuan Chang

¹Department of Chemical Engineering, National Yunlin University of Science and Technology, Touliu, Taiwan, ROC. weiwu@yuntech.edu.tw

Bioprocess and Biosystems Engineering

|October 4, 2005

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This study develops a simplified nonlinear control model for continuous bioreactors using a pseudo-steady-state approach to manage oscillations in microbial cell cultures. The proposed nonlinear PI controllers demonstrate effective regulatory and tracking performance without needing on-line sensors.

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