Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Methodology of mapping quantitative trait loci for discrete traits using maximum likelihood].

Zong-Jun Yin1, Qin Zhang, Hong-Quan Chen

  • 1College of Animal Science and Technology, China Agricultural University, Beijing 100094, China. yinzongjun@yahoo.com.cn

Yi Chuan Xue Bao = Acta Genetica Sinica
|October 6, 2005
PubMed
Summary

The threshold model offers superior parameter estimation for quantitative trait loci (QTL) mapping in discrete traits. Increased QTL effect, heritability, and incidence enhance QTL detection accuracy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic Accuracy of Dermoscopic Characteristics in Cutaneous Squamous Cell Carcinoma: A Retrospective Analysis.

Journal of skin cancer·2025
Same author

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response.

Cell reports·2025
Same author

Mapping the genetic landscape establishing a tumor immune microenvironment favorable for anti-PD-1 response in mice and humans.

bioRxiv : the preprint server for biology·2024
Same author

Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy.

Journal of immunology (Baltimore, Md. : 1950)·2024
Same author

Inhibition of RhoGEF/RhoA alleviates regorafenib resistance and cancer stemness via Hippo signaling pathway in hepatocellular carcinoma.

Experimental cell research·2024
Same author

Global and tissue-specific aging effects on murine proteomes.

Cell reports·2023

Area of Science:

  • Quantitative genetics
  • Statistical genomics

Context:

  • Comparing statistical models for genetic analysis.
  • Evaluating factors influencing genetic trait detection.

Purpose:

  • To compare the efficiency of interval mapping using threshold versus linear models.
  • To investigate the impact of genetic and trait-specific factors on quantitative trait loci (QTL) detection efficiency.

Summary:

  • Utilized maximum likelihood and simulation to assess interval mapping models.
  • Applied a daughter design with 500 individuals across multiple families.
  • The threshold model demonstrated superior parameter estimation and accuracy for discrete traits compared to the linear model.
  • Identified QTL effect, heritability, and trait incidence as key factors directly influencing QTL mapping accuracy.

Related Experiment Videos

Impact:

  • Provides evidence for the threshold model's advantage in mapping discrete traits.
  • Highlights critical factors for optimizing QTL detection strategies.
  • Informs future genetic studies aiming for precise trait-associated locus identification.