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Updated: Aug 15, 2026

Luminophore Formation in Various Conformations of Bovine Serum Albumin by Binding of Gold(III)
Published on: August 31, 2018
[Synthesis of substituted 3H-indole quaternary ammonium salt and study on its interaction with bovine serum albumin
Tong-kuan Xu1, Xing-hai Shen, Hong-cheng Gao
1College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Abstract:
A substituted 3H-indole quaternary ammonium molecule was designed and synthesized using hexamethylphosphoramide (HMPA) as a solvent. The products were purified and characterized by IR, 1H-NMR, MS and elemental analysis. The binding reaction of this compound with bovine serum albumin (BSA) in aqueous solution was studied using fluorescence. Their binding constant is Ka = 1.995 x 10(5) dm3 x mol(-1) and the binding site number is n = 1.12. It is confirmed that the combination is a single static quenching process.
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