Related Experiment Video
Updated: Jul 8, 2026
10:17
Switchable Acoustic and Optical Resolution Photoacoustic Microscopy for In Vivo Small-animal Blood Vasculature Imaging
Published on: June 26, 2017
Dynamic chiral selection and amplification using photoresponsive organogelators
Jaap J D de Jong1, Theodora D Tiemersma-Wegman, Jan H van Esch
1Laboratory of Organic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Journal of the American Chemical Society
|October 6, 2005
Summary
Researchers developed a method to control chiral molecular aggregation using complementary chiral switches. This technique achieved high enantiomeric excess, offering new possibilities for chiral system applications.
Area of Science:
- Supramolecular Chemistry
- Chiral Systems
- Molecular Switches
Background:
- Dynamic equilibria in chiral systems are crucial for natural processes and applications.
- Controlling the aggregation and conformation of chiral molecules remains a challenge.
Purpose of the Study:
- To investigate the selective coaggregation of a nonchiral diarylethene switch with complementary chiral switches.
- To achieve high enantiomeric excess by locking dynamic equilibria in a gel state.
Main Methods:
- Utilizing complementary chiral switches (1 and 2) to induce selective coaggregation of a nonchiral diarylethene switch (3).
- Employing gel state conditions to stabilize the aggregated conformations.
- Analyzing the enantiomeric excess of the resulting chiral aggregates.
Main Results:
- Selective coaggregation of switch 3 was achieved by chiral switches 1 and 2.
- Enantiomeric excess as high as 94% was observed, indicating successful locking of dynamic equilibria.
- Opposite chiral induction was observed despite the consistent R conformation of switches 1 and 2.
Conclusions:
- The study demonstrates a novel method for controlling chiral aggregation and amplifying dynamic equilibria.
- This approach offers precise control over molecular conformation and chirality in supramolecular assemblies.
- The findings have implications for the design of advanced chiral materials and enantioselective processes.
