Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Constructing circuits: neurogenesis and migration in the developing neocortex.

Arnold R Kriegstein1

  • 1Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA. kreigstein@stemcell.ucsf.edu

Epilepsia
|October 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TGFb signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration.

The Journal of clinical investigation·2026
Same author

Embryonic MGE Precursor Cells Grafted into Adult Rat Striatum Integrate and Ameliorate Motor Symptoms in 6-OHDA-Lesioned Rats.

Cell stem cell·2026
Same author

Single-cell proteomic landscape of the developing human brain.

Nature biotechnology·2026
Same author

The need for a global effort to attend to human neural organoid and assembloid research.

Science (New York, N.Y.)·2025
Same author

The new frontier in understanding human and mammalian brain development.

Nature·2025
Same author

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation.

Neuron·2025
Same journal

Semiology of functional/dissociative seizures in idiopathic generalized epilepsy: An inpatient video-electroencephalographic study.

Epilepsia·2026
Same journal

Perineuronal net abnormalities in epileptic human tissue.

Epilepsia·2026
Same journal

Cortical stimulation reveals effective disconnection of the epileptogenic network at seizure onset.

Epilepsia·2026
Same journal

Anterior cingulate cortex neuron subtypes differentially regulate seizures.

Epilepsia·2026
Same journal

Ultrafast oscillations in the human brain and their functional significance.

Epilepsia·2026
Same journal

Magnetoencephalographic source imaging improves localization of the epileptogenic zone in multimodal imaging evaluation.

Epilepsia·2026
See all related articles

Neural stem cells, radial glia, generate neurons through complex divisions and migrations. Astrocytes may retain neurogenesis potential, offering therapeutic insights for developmental disorders.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Traditionally, glial and neuronal cells were considered separate lineages.
  • Recent discoveries reveal a more complex relationship, particularly involving radial glia.

Purpose of the Study:

  • To update the understanding of neuronal development, focusing on proliferation, migration, and differentiation.
  • To explore the roles of radial glia, intermediate precursor cells, and interneurons in cortical development.

Main Methods:

  • Review of recent findings in neuronal development.
  • Analysis of cell division patterns (asymmetric and symmetric).
  • Examination of neuronal migration pathways and stages.

Main Results:

Related Experiment Videos

  • Radial glia function as neural stem cells, generating pyramidal neurons.
  • Pyramidal neurons undergo multi-stage migration with shape and directional changes.
  • Inhibitory interneurons originate outside the cortex and migrate tangentially.
  • Gamma-aminobutyric acid (GABA) may coordinate neuronal generation and migration.
  • Radial glia transform into astrocytes post-neurogenesis, potentially retaining neurogenic capacity.

Conclusions:

  • Neuronal development is more dynamic than previously thought, involving glial cells as progenitors.
  • Understanding these mechanisms provides insight into developmental disorders.
  • Potential therapeutic interventions for neurological conditions are suggested.