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Published on: March 3, 2023
[Expression and clinical significance of decorin in stress urinary incontinence]
1Department of Obstetrics and Gynecology, Fuzhou General Hospital, Nanjing Military Command, Fuzhou 350025, China.
Objective:
To observe the relation between content of type III collagen and expression of decorin in paraurethral connective tissue in patients with stress urinary incontinence (SUI).
Methods:
Transvaginal biopsies were obtained from the paraurethral connective tissue in 43 SUI and non-SUI control women. The concentration of type III collagen was determined by immunohistochemical technique, electrophoretic separation and quantification. RT-PCR was used to verify the mRNA level of decorin.
Results:
The mean concentration of type III collagen was significantly reduced in patients with SUI (23 +/- 4), compared to the control group (34 +/- 6, P < 0.05). The expression of decorin was significantly higher in patients with SUI (1.17 +/- 0.18), compared to the control group (0.76 +/- 0.16, P < 0.05), and it was highly and negatively related to the content of type III collagen (r = -0.720, P < 0.05).
Conclusions:
Our study results suggest that collagen metabolism in SUI is altered by decorin. This alteration results in a less flexible connective tissue, which is probably more likely to break. Decorin might be involved in the pathogenesis of SUI.
