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Grey matter loss in relapsing-remitting multiple sclerosis: a voxel-based morphometry study.

A Prinster1, M Quarantelli, G Orefice

  • 1Biostructure and Bioimaging Institute, National Council for Research, Edificio 10, Via Pansini, 5, 80131 Napoli, Italy. anna.prinster@ibb.cnr.it

Neuroimage
|October 6, 2005
PubMed
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Multiple sclerosis (MS) causes grey matter (GM) loss, particularly in the left fronto-temporal cortex and deep brain structures. This GM reduction in relapsing-remitting MS correlates with lesion load but not disease duration.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Multiple Sclerosis (MS) is characterized by global grey matter (GM) loss.
  • Understanding the precise localization of GM loss is crucial for disease management.

Purpose of the Study:

  • To investigate the specific locations of grey matter volume reduction in patients with relapsing-remitting MS.
  • To assess brain asymmetry in grey matter distribution between MS patients and healthy controls.

Main Methods:

  • Optimized voxel-based morphometry applied to MRI scans of 51 MS patients and 34 controls.
  • Voxel-wise comparison of segmented GM volumes to identify regions of significant GM loss.
  • Assessment of GM asymmetry by comparing interhemispheric GM differences.

Related Experiment Videos

Main Results:

  • Significant GM reduction observed in the left fronto-temporal cortex, precuneus, anterior cingulate gyrus, and bilateral caudate nuclei in MS patients.
  • Preferential left-sided GM loss was confirmed, correlating with increased GM asymmetry (Left < Right).
  • Caudate atrophy correlated with lesion load; no correlation found between cortical GM loss and disease duration, clinical status, or lesion load.

Conclusions:

  • Cortical GM reduction in relapsing-remitting MS primarily affects left fronto-temporal structures and deep GM.
  • Deep GM atrophy shows a preferential correlation with overall lesion burden in MS.