Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Trefoil factor 1 (pS2/TFF1), a peptide with numerous functions].

Carole Mathelin1, Catherine Tomasetto, Marie-Christine Rio

  • 1Centre de lutte contre le cancer Paul Strauss, 3, rue de la Porte de l'Hôpital, 67085 Strasbourg Cedex.

Bulletin Du Cancer
|October 6, 2005
PubMed
Summary

Trefoil Factor 1 (TFF1), also known as pS2, is crucial for mucosal healing and acts as a tumor suppressor. TFF1 overexpression is linked to better outcomes in various cancers, particularly breast cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution of germline testing, mutation spectrum and clinico-pathological features in male breast cancer: a 27-year retrospective cohort including 69 patients.

Cancer genetics·2026
Same author

Survey of the Senologic International Society (SIS) on the Use of Preoperative Breast MRI in Early-Stage Breast Cancer: A Global Perspective on Current Practice.

European journal of breast health·2026
Same author

In vitro methods for studying protein-lipid droplet interactions.

Methods in enzymology·2026
Same author

STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch.

The EMBO journal·2026
Same author

Contralateral Risk Reduction Mastectomy in Patients With Unilateral Breast Cancer Scheduled for Mastectomy: A Multidisciplinary Survey; Physicians' Perspective.

Clinical breast cancer·2026
Same author

[(Even) less axillary surgery for breast cancer?]

Gynecologie, obstetrique, fertilite & senologie·2026

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • The trefoil factor (TFF) family, comprising TFF1 (pS2), TFF2 (SP), and TFF3 (ITF), is integral to epithelial cell function.
  • TFFs are vital for mucosal defense, repair, and regeneration following injury or inflammation.

Purpose of the Study:

  • To elucidate the specific roles of TFF1 (pS2) in epithelial restitution and its implications in cancer.
  • To investigate the association between TFF1 expression and tumor suppressor activity, prognosis, and therapeutic response in various carcinomas.

Main Methods:

  • Review of existing literature on TFF family members and their functions.
  • Analysis of studies reporting TFF1 expression levels in different cancer types.
  • Correlation analysis of TFF1 overexpression with patient prognosis and treatment outcomes.

Related Experiment Videos

Main Results:

  • TFF1 (pS2) exhibits distinct functions compared to other TFFs, notably acting as a suppressor gene in gastric tumors.
  • Overexpression of TFF1 has been observed across multiple carcinomas, including breast, bowel, prostate, pancreas, thyroid, and lung cancers.
  • In breast cancer, TFF1 overexpression correlates with a favorable prognosis and predicts a positive response to hormonotherapy.

Conclusions:

  • TFF1 (pS2) plays a significant role in epithelial regeneration and possesses tumor-suppressive properties.
  • TFF1 overexpression is a potential biomarker for improved prognosis and predicting treatment efficacy in several types of cancer, especially breast cancer.