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Updated: Aug 15, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
Published on: March 5, 2022
No association between insulin resistance and preeclampsia
E Salamalekis1, N Vitoratos, E Makrakis
12nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece. emakrakis@hotmail.com
Objective:
To investigate the possible link between insulin resistance and preeclampsia.
Methods:
The study included 30 primigravidas between 28 and 34 weeks of gestation. The study subjects were divided into two groups: Group A consisted of 15 normotensive women of a mean gestational age of 31.6 weeks and group B consisted of 15 preeclamptic women of a mean gestational age of 29.9 weeks. Glucose and insulin levels were measured at 0, 1 and 2 h of an OGTT (after 75 g oral glucose administration). Insulin resistance and sensitivity were evaluated with the use of IR HOMA, QUICKI and IS OGTT.
Results:
Glucose and insulin levels at 0, 1 and 2 h of the OGTT as well as IR HOMA, QUICKI and IS OGTT were comparable between preeclamptic and normotensive pregnant women.
Conclusions:
Our results indicate that preeclampsia is not associated with hyperinsulinaemia and/or insulin resistance, in either the fasting or the postprandial state.
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