Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phase transformations in a model mesenchymal tissue.

Stuart A Newman1, Gabor Forgacs, Bernhard Hinner

  • 1Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA. newman@nymc.edu

Physical Biology
|October 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Removal of multiple foreign bodies from the head region via endonasal, transoral, and transcutaneous approaches].

Orvosi hetilap·2026
Same author

Opposing Human Genetic Engineering.

The CRISPR journal·2025
Same author

Form, function, mind: What doesn't compute (and what might).

Biochemical and biophysical research communications·2024
Same author

Implementing governmental oversight of enhanced potential pandemic pathogen research.

Journal of virology·2024
Same author

Reply to Luger, "Why Is It So Hard to Find Persistent Borreliella burgdorferi?"

mBio·2022
Same author

Borreliella burgdorferi Antimicrobial-Tolerant Persistence in Lyme Disease and Posttreatment Lyme Disease Syndromes.

mBio·2022
Same journal

Quantitative models of photoreceptor metabolisms: implications for rod outer segment length, retinal glycolysis and choroidal blood flow.

Physical biology·2026
Same journal

Mechanical interactions govern self-organized ordering in bacterial colonies on surfaces.

Physical biology·2026
Same journal

Robust chemotaxis beyond sensing limits: signal, noise, and strategy.

Physical biology·2026
Same journal

Ecological dynamics of pro-tumor and anti-tumor teams in the tumor microenvironment.

Physical biology·2026
Same journal

Swarms of female<i>Anopheles gambiae</i>mosquitoes may fracture when perturbed.

Physical biology·2026
Same journal

How exercise scheduling affects IL-6-mediated tumor suppression: a fixed exercise volume perspective.

Physical biology·2026
See all related articles

Adding collagen-binding beads to developing connective tissues accelerates network formation. This significantly alters matrix properties, impacting tissue development and engineered substitutes.

Area of Science:

  • Biomaterials Science
  • Developmental Biology
  • Tissue Engineering

Background:

  • Connective tissues comprise cells within extracellular matrices (ECMs).
  • Immature connective tissues (mesenchymes) feature randomly arranged fibers that assemble into networks.
  • In vitro collagen-latex bead composites model mesenchyme physical properties.

Purpose of the Study:

  • To investigate how particle presence affects collagen assembly and ECM properties.
  • To understand topological transitions in developing connective tissues.
  • To model cell-induced microdomain formation in tissues.

Main Methods:

  • Utilized in vitro collagen solutions with collagen-binding polystyrene latex beads.
  • Monitored sol-gel transition kinetics during collagen assembly.

Related Experiment Videos

  • Analyzed viscoelastic properties of the resulting collagen matrix.

    • Main Results:

    • Beads above a critical density accelerate the collagen sol-gel transition.
    • Suprathreshold bead density alters matrix viscoelasticity at critical collagen concentrations.
    • Particle presence influences the formation of a globally interconnected fiber network.

    Conclusions:

    • Particle-induced changes in fiber organization can lead to distinct tissue microdomains.
    • This model provides insights into phase transformations in biomaterials.
    • Findings are relevant for understanding developing/healing tissues and tissue substitutes.