Related Experiment Video
Updated: Aug 15, 2026

08:27
The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
Published on: July 25, 2011
[Brain protection during ischemia: state-of-the-art]
Anesteziologiia I Reanimatologiia
|October 7, 2005
Abstract:
The paper reviews the studies dealing with cerebral ischemia and neuroprotection. On this basis, the authors make conclusions on the perspectives of development of this direction and indicate the difficulties investigators and practitioners face in solving the problems in the protection of the brain from local and global ischemic lesion. Current views of the effectiveness of drugs and procedures used in daily practice and the authors' own experience in solving this topical anesthesiological and resuscitative problem are given.
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

