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Related Experiment Videos

Large-scale databases in toxicogenomics.

A Hugh Salter1

  • 1Department of Molecular Sciences, AstraZeneca R&D, Södertälje, S-151 87 Södertälje, Sweden. Hugh.Salter@astrazeneca.com

Pharmacogenomics
|October 7, 2005
PubMed
Summary
This summary is machine-generated.

Genomics offers great potential for improving molecular safety assessments by enhancing mechanistic understanding and compound prediction. Standardization of biological and technical issues is crucial for operationalizing emerging toxicogenomics databases.

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Informatics and multivariate analysis of toxicogenomics data.

Current opinion in drug discovery & development·2003
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Area of Science:

  • Toxicogenomics
  • Molecular Safety Assessment
  • Genomic Applications

Background:

  • Genomics presents a promising avenue for advancing molecular strategies in safety assessment.
  • There is a growing need for improved mechanistic understanding and prediction of unknown compounds.

Purpose of the Study:

  • To highlight the potential of genomics in safety assessment.
  • To discuss the emergence of public toxicogenomics initiatives and supporting infrastructure.
  • To emphasize the need for standardization in toxicogenomics.

Main Methods:

  • Review of ongoing public toxicogenomics initiatives.
  • Analysis of emerging mechanistic findings in the field.
  • Identification of developing databases and standards.

Main Results:

  • Mechanistic findings from toxicogenomics initiatives are becoming evident.
  • Databases and standards are being developed to support these efforts.
  • Significant progress is being made in applying genomics to safety evaluations.

Conclusions:

  • Genomics holds immense promise for revolutionizing molecular safety assessment.
  • Standardization is essential for the successful implementation and operation of community toxicogenomics databases.
  • Further attention to standardization will facilitate the full potential of these initiatives.