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In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
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In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse

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[Cellular mechanisms of thyroid hormone action]

S Vinzio1, O Morel, J-L Schlienger

  • 1Service de médecine interne et nutrition, Hôpital Hautepierre, av. Molière, 67098 Strasbourg cedex 67, France. stephane.vinzio@chru-strasbourg.fr

Presse Medicale (Paris, France : 1983)
|October 7, 2005
PubMed
Abstract

Insights

Thyroid hormones, including free 3,53'-L-triiodothyronine (FT3), impact heart and blood vessel cells. These hormones influence cardiac contractility and vascular resistance, explaining symptoms seen in thyroid dysfunction like hyperthyroidism.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Molecular Biology

Background:

  • Thyroid hormones are crucial regulators of cellular function.
  • Cardiac myocytes and vascular cells are key targets of thyroid hormone action.
  • Dysregulation of thyroid hormones leads to significant cardiovascular manifestations.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which thyroid hormones affect cardiac and vascular cells.
  • To explain the cardiac manifestations associated with thyroid dysfunction, particularly hyperthyroidism.

Main Methods:

  • Analysis of genomic and non-genomic effects of thyroid hormones.
  • Investigation of protein modulation, including myosin heavy chains and Ca2+ATPase.
  • Examination of effects on ion channels and membrane receptors in cardiac and vascular cells.

Main Results:

  • Free 3,53 -L-triiodothyronine (FT3) and its receptor modulate key contractile proteins (myosin heavy chains) and calcium handling (sarcoplasmic reticulum Ca2+ATPase).
  • Thyroid hormones exert rapid, non-genomic effects on sinoatrial node channels and receptors.
  • Thyroid hormones reduce systemic vascular resistance by affecting vascular smooth muscle and endothelial cells.

Conclusions:

  • Thyroid hormones significantly impact cardiac myocyte contractility and vascular tone.
  • Genomic and non-genomic actions of thyroid hormones contribute to cardiovascular regulation.
  • The cardiac and vascular effects of thyroid hormones provide a comprehensive explanation for clinical findings in dysthyroidism, especially hyperthyroidism.

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