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[Research on extracting process for Fengshitongbi capsules].
Wei He1, Xuemei Shen, Zhijian Fang
1Guangdong College of Pharmacy, Guangzhou 510240.
Summary
Optimal extraction methods for Fengshitongbi capsule were identified using orthogonal tests. This research enhances the extraction of active components from Flos Lonicerae, Caulis Sinomenii, and Rhizoma Smilacis Glabrae.
Area of Science:
- Traditional Chinese Medicine
- Pharmacognosy
- Chemical Engineering
Background:
- Fengshitongbi capsule is a traditional Chinese medicine formulation.
- Effective extraction of active compounds is crucial for therapeutic efficacy.
- Optimizing extraction parameters ensures consistent product quality.
Purpose of the Study:
- To determine the optimal extraction technology for Fengshitongbi capsule.
- To maximize the yield of key active components.
Main Methods:
- Orthogonal experimental design was employed to optimize extraction parameters.
- High-Performance Liquid Chromatography (HPLC) was used to quantify Chlorogenic acid.
- Thin-Layer Chromatography (TLC) scanning determined Sinomenine content.
Main Results:
- Optimal extraction for Flos Lonicerae: 6 volumes of water, 3 extractions, 30 minutes each.
- Optimal extraction for Caulis Sinomenii and Rhizoma Smilacis Glabrae: 7 volumes of 70% ethanol, 2 extractions, 90 minutes each.
- These conditions yielded a considerable extraction rate of active components.
Conclusions:
- The established extraction technology significantly improves the recovery of active compounds.
- This optimized method ensures the quality and efficacy of Fengshitongbi capsule.
- The findings provide a scientific basis for the industrial production of the capsule.