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Updated: Aug 15, 2026

Comparative RNA Structure Analysis of Nascent and Mature Transcripts in Saccharomyces cerevisiae
Published on: February 27, 2026
[Role of AURE sequences in the regulation of mRNA stability]
Dominika Trzaska1, Jarosław Dastych
1Laboratory of Molecular Immunology, International Institute of Molecular and Cell Biology, 4 Ks. Trojdena St., 02-109 Warsaw, Poland. nika@iimcb.gov.pl
Abstract:
Post-transcriptional processes influencing mRNA stability are an important control point in gene expression regulation. The best-studied regulatory elements controlling mRNA stability are AU-rich sequences (AURE) found in 3'UTRs of many genes coding cytokines and stress response proteins. The presence of these elements results in short half-life of mRNA, but such mRNA half-life is prolonged upon cell stimulation or exposition to stress factors. Research on AURE-mediated mRNA decay resulted in discovery of AURE-binding proteins and in elucidating signal transduction pathways involved in the process of mRNA stability regulation. Defects in mRNA stability regulation can result in diseases such as lymphomas, neuromas or immunological and inflammatory disorders.
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