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Related Experiment Videos

How do CD4+CD25+ regulatory T cells control autoimmunity?

Jeffrey A Bluestone1, Qizhi Tang

  • 1University of California at San Francisco Diabetes Center, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, California 94143-0540, USA. jbluest@diabetes.ucsf.edu

Current Opinion in Immunology
|October 8, 2005
PubMed
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Regulatory T cells (Tregs), crucial for controlling autoimmunity, have a complex mechanism of action. Recent studies suggest Tregs modulate pathogenic T cells by influencing antigen-presenting cells in vivo.

Area of Science:

  • Immunology
  • T cell biology
  • Autoimmunity

Background:

  • Regulatory T cells (Tregs), formerly suppressor T cells, are a key focus in immunology.
  • Tregs are essential for preventing autoimmunity and have a unique T cell lineage.
  • The CD4(+)CD25(+)Foxp3(+) Treg subset originates in the thymus and can be induced peripherally.

Purpose of the Study:

  • To clarify the mechanism of action of regulatory T cells (Tregs).
  • To reconcile discrepancies between in vitro and in vivo Treg studies.

Main Methods:

  • In vivo analyses of Treg function.
  • Investigation of Treg interactions with antigen-presenting cells.

Main Results:

  • Recent in vivo studies provide evidence for Treg mechanisms.

Related Experiment Videos

  • Tregs appear to influence pathogenic T cell activation and differentiation.
  • Antigen-presenting cells are implicated as mediators of Treg effects.

    • Conclusions:

    • Treg mechanisms are better understood through in vivo studies.
    • Tregs regulate autoimmunity by modulating immune responses via antigen-presenting cells.