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Updated: Aug 15, 2026
Prehospital Thrombolysis: A Manual from Berlin
Published on: November 26, 2013
Thrombolysis beyond the guidelines: two treatments in one subject within 90 hours based on a modified magnetic
Raffi Topakian1, Franz Gruber, Franz A Fellner
1Department of Neurology, Hospital Wagner-Jauregg Linz, Austria. raffi.topakian@aon.at
Background And Purpose:
We report the first case of 2 intravenous thrombolysis treatments within 90 hours in a patient with early recurrent stroke.
Summary Of Review:
A 50-year-old man had improved significantly after intravenous thrombolysis for acute stroke. On the fourth day, he deteriorated dramatically because of recurrent stroke. Evidence of vessel reocclusion and profound perfusion/diffusion mismatch constituted the rationale for a second thrombolysis treatment, which resulted in vessel recanalization and significant neurologic improvement.
Conclusions:
The pathophysiological information obtained by multimodal magnetic resonance imaging may suit as a brain clock when repeat thrombolysis treatment is considered for early recurrent stroke.
