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Related Experiment Videos

Gastric carcinoids: a temporal increase with proton pump introduction.

N Hodgson1, L G Koniaris, A S Livingstone

  • 1Dewitt Daughtry Department of Surgery and the Sylvester Comprehensive Cancer Center, University of Miami, 3550 Sylvester Comprehensive Cancer Center (310T), 1475 NW 12th Avenue, Miami, FL 33136, USA.

Surgical Endoscopy
|October 8, 2005
PubMed
Summary

Gastric carcinoid tumors show a significant increase in incidence, rising eight- to ninefold over two decades. This trend may be linked to increased proton pump inhibitor use and improved endoscopic detection methods.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Epidemiology

Background:

  • Recent reports indicate a rising incidence of gastric carcinoids.
  • This study evaluates the incidence pattern of gastric carcinoids in two large population-based cancer registries.

Purpose of the Study:

  • To evaluate the incidence pattern of gastric carcinoids.
  • To analyze trends in gastric carcinoid incidence over a 20-year period.

Main Methods:

  • Utilized data from the Florida Cancer Data System (FCDS) and the Surveillance, Epidemiology, and End Results (SEER) program.
  • Analyzed all identified gastric carcinoid cases from January 1981 to December 2000.
  • Calculated descriptive statistics and age-adjusted incidence rates.

Main Results:

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  • Identified 326 (FCDS) and 594 (SEER) cases of invasive gastric carcinoid.
  • Observed a significant increase in age-adjusted incidence rates, from 0.04 to 0.18 per 100,000 by 2000.
  • Reported an annual percentage increase of 8.17% (FCDS) and 9.17% (SEER), contrasting with a decrease in overall gastric cancer incidence.

Conclusions:

  • Documented a statistically significant eight- to ninefold increase in gastric carcinoid incidence.
  • Correlated the temporal increase with the widespread use of proton pump inhibitors and improved endoscopic detection.
  • Recommended further epidemiologic studies to investigate these trends.