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[Celiac disease in disguise].
1Gottardi et Philippe de Saussure Service de gastroentérologie et d'hépatologie, HUG. andrea.degottardi@hcuge.ch
Revue Medicale Suisse
|October 11, 2005
Summary
Celiac disease often affects adults with varied symptoms beyond classic signs. Early diagnosis is aided by reliable antitransglutaminase antibody testing, improving patient outcomes.
Area of Science:
- Gastroenterology
- Immunology
- Internal Medicine
Context:
- Celiac disease is often misdiagnosed in adults due to atypical presentations.
- Classical symptoms like diarrhea and weight loss are infrequent in adult celiac disease.
- Associated conditions include iron deficiency, vitamin D deficiency, and type 1 diabetes.
Purpose:
- To review the diverse clinical manifestations of celiac disease in adults.
- To highlight the importance of considering celiac disease in non-classical presentations.
- To provide guidance on the interpretation and use of serological tests for diagnosis.
Summary:
- Celiac disease frequently presents atypically in adults, not solely with diarrhea, weight loss, and nutritional deficiencies.
- Common associations include irritable bowel syndrome-like symptoms and type 1 diabetes.
- Antitransglutaminase antibody testing offers a simple, sensitive, and specific diagnostic method.
Impact:
- Clinicians should consider celiac disease in a broader range of clinical scenarios.
- Improved diagnostic strategies can lead to earlier identification and management of celiac disease.
- Understanding atypical presentations enhances diagnostic accuracy and patient care.