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Related Experiment Videos

Oxygen kinetics in experimental sepsis.

R B Hirschl1, K F Heiss, R E Cilley

  • 1Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0331.

Surgery
|July 1, 1992
PubMed
Summary
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In sepsis, oxygen consumption (VO2) remains independent of oxygen delivery (DO2) until a critical threshold is reached, refuting the idea of continuous supply dependency. Mixed venous oxygen saturation (SvO2) reliably indicates this critical point.

Area of Science:

  • Physiology
  • Critical Care Medicine
  • Metabolic Studies

Background:

  • Systemic oxygen delivery (DO2) typically exceeds oxygen consumption (VO2), with VO2 being independent of DO2.
  • A DO2/VO2 ratio below two suggests anaerobic metabolism and supply dependency.
  • Some research suggests sepsis and ARDS alter this relationship, causing continuous supply dependency.

Purpose of the Study:

  • To investigate the relationship between oxygen delivery and consumption in a canine model of peritonitis (sepsis).
  • To determine if sepsis induces a state of continuous VO2 supply dependency.
  • To identify critical thresholds for VO2 supply dependency during sepsis.

Main Methods:

  • Created a canine peritonitis model to induce sepsis.
  • Regulated DO2 using controlled pericardial tamponade.

Related Experiment Videos

  • Measured VO2 and DO2, calculating the DO2/VO2 ratio.
  • Monitored mixed venous oxygen saturation (SvO2).

    • Main Results:

    • Sepsis increased VO2 by 28%.
    • VO2 remained independent of DO2 when the DO2/VO2 ratio was above 2.4.
    • At DO2/VO2 ratios below 2.4, VO2 became supply-dependent and decreased rapidly.
    • A critical SvO2 of 42% +/- 12% correlated with the onset of VO2 supply dependency.

    Conclusions:

    • In this septic dog model, VO2 is not continuously supply-dependent; it remains independent of DO2 when delivery is adequate.
    • A critical DO2/VO2 ratio (and corresponding SvO2) marks the transition to supply dependency.
    • SvO2 effectively reflects the DO2/VO2 relationship and the onset of supply dependency in sepsis.