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Updated: Aug 15, 2026

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
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The lymphatic vasculature: recent progress and paradigms

Guillermo Oliver1, Kari Alitalo

  • 1Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. guillermo.oliver@stjude.org

Annual Review of Cell and Developmental Biology
|October 11, 2005
PubMed

The field of lymphatic research has been recently invigorated by the identification of genes and mechanisms that control various aspects of lymphatic development. We are beginning to understand how, starting from a subgroup of embryonic venous endothelial cells, the whole lymphatic system forms in a stepwise manner. The generation of genetically engineered mice with defects in different steps of the lymphangiogenic program has provided models that are increasing our understanding of the lymphatic system in health and disease. This knowledge, in turn, should lead to the development of better diagnostic methods and treatments of lymphatic disorders and tumor metastasis.

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