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Mycophenolate mofetil in pediatric renal transplantation

H Otukesh1, M Sharifian, A Basiri

  • 1Hospital Ali Asghar, Tehran, Iran. hasanotukesh@yahoo.com

Transplantation Proceedings
|October 11, 2005
PubMed

Insights

Mycophenolate mofetil (MMF) improves graft survival and function in pediatric kidney transplant patients compared to azathioprine (AZA). MMF is particularly effective in managing chronic rejection and preventing early graft loss.

Area of Science:

  • Pediatric Nephrology
  • Transplant Immunology
  • Immunosuppression Therapy

Background:

  • Kidney transplantation is the preferred treatment for pediatric end-stage renal disease (ESRD).
  • Investigating the efficacy of mycophenolate mofetil (MMF) in pediatric renal transplant recipients is crucial.

Purpose of the Study:

  • To evaluate the impact of MMF on graft survival and function in children undergoing renal transplantation.
  • To compare MMF with azathioprine (AZA) as an immunosuppressive agent in this population.

Main Methods:

  • A retrospective study of 216 children who received renal transplants between 1985 and 2003.
  • 100 patients received MMF (cases), while 116 patients received AZA (controls), both in combination with cyclosporine and prednisolone.

Main Results:

  • The MMF group demonstrated superior graft survival and function compared to the AZA group.
  • Immediate post-transplant MMF administration reduced graft loss and acute rejection episodes within the first 3 months.
  • MMF treatment for chronic rejection stabilized renal function and significantly improved graft survival compared to AZA.

Conclusions:

  • MMF shows promise in halting graft dysfunction associated with chronic rejection.
  • This immunosuppressive agent enhances both short-term and long-term graft survival in pediatric renal transplant recipients.
Abstract

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