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Dermal exposure of hexachlorophene to guinea pigs
A K Mathur1, B N Gupta, R Shanker
1Industrial Toxicology Research Centre, Lucknow, India.
Veterinary and Human Toxicology
|February 1, 1992
Abstract:
The skins of guinea pigs were exposed to 50 mg/kg hexachlorophene (HCP) for 7, 15 or 30 days. The activities of skin marker enzymes (beta-glucuronidase, histidase, tyrosinase) increased, but glutathione decreased. Lipid peroxidation and histamine contents increased during different time intervals. The histopathological changes showed damage to epidermis and dermis. Depending on the duration of exposure, HCP produces biochemical and histopathological damage to skin.