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High-density lipoprotein particles may regulate hemostasis in human pregnancy

Luís Belo1, Alice Santos-Silva, Gordon Lowe

  • 1Department of Biochemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal. luis_fbelo@yahoo.com

Fertility and Sterility
|October 11, 2005
PubMed

We explored the association of apolipoprotein A-I (the major protein constituent of high-density lipoprotein (HDL)) and fibrin fragment D-dimer (a marker of cross-linked fibrin turnover) in pregnant women. A significant inverse correlation between the levels of apolipoprotein A-I and fibrin fragment D-dimer was observed in both pre-eclamptic and normal pregnant women (rs = -0.459, n = 37 and rs = -0.290, n = 55, respectively), suggesting a major regulating role of HDL in hemostasis during pregnancy.

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