Related Experiment Video
Updated: Aug 15, 2026

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease
Martina Schüller1, Dieter Jenne, Raymond Voltz
1Department of Clinical Neuroimmunology, Klinikum Grosshadern,Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany.
Abstract:
Using sera from patients with paraneoplastic neurological syndromes, several novel neuronal autoantigens such as the paraneoplastic Ma antigens (PNMA) have been identified. Here, we report the correction and completion of the previously published prototype member PNMA1, the brain and testis restricted expression of a third member (PNMA3) and the sequences for further partially uncharacterized members of this novel neuronal protein family. Murine and rat orthologs exist for this protein family. By analogy to the pro-apoptotic MOAP1, similar functional interactions may exist between members of the PNMA family and the bcl-2 family.
Related Concept Videos
Neural Regulation
Parkinson Disease ll: Pathophysiology
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

