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Related Experiment Videos

Pentane-1,5-diol as a percutaneous absorption enhancer.

Jan Faergemann1, Björn Wahlstrand, Thomas Hedner

  • 1Department of Dermatology, Sahlgrenska University Hospital, SE-41345, Gothenburg, Sweden. jan.faergemann@derm.gu.se

Archives of Dermatological Research
|October 11, 2005
PubMed
Summary
This summary is machine-generated.

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Pentane-1,5-diol enhances drug delivery and improves cosmetic properties in topical formulations. This diol offers a safer, more effective alternative to propylene glycol for dermatological applications.

Area of Science:

  • Dermatology
  • Cosmetic Science
  • Pharmaceutical Science

Background:

  • Propylene glycol is the standard diol in dermatology.
  • Pentane-1,5-diol, traditionally used in industrial applications, possesses solvent, water-binding, antimicrobial, and preservative properties.
  • These properties suggest pentane-1,5-diol's potential utility in skin compositions.

Purpose of the Study:

  • To compare pentane-1,5-diol with other diols (propane-1,2-diol and 2-methyl-pentane-2,4-diol) as penetration enhancers in dermatological preparations.
  • To evaluate the impact of pentane-1,5-diol on the release and absorption of active pharmaceutical ingredients (APIs).
  • To assess the cosmetic properties and safety profile of pentane-1,5-diol in topical formulations.

Main Methods:

  • Comparative study of diols as penetration enhancers.

Related Experiment Videos

  • Measurement of tri-iodothyroacetic acid (TRIAC) release.
  • Quantification of percutaneous absorption of hydrocortisone and mometasone furoate.
  • Evaluation of cosmetic attributes and safety (skin/eye irritation, odor).

    • Main Results:

    • Pentane-1,5-diol increased TRIAC release by 21% compared to propane-1,2-diol.
    • Hydrocortisone absorption into the skin was 50% higher with pentane-1,5-diol versus propane-1,2-diol.
    • Mometasone furoate cream with pentane-1,5-diol showed comparable API absorption but superior cosmetic properties (odor, texture, greasiness) and no significant difference in skin/through-skin absorption compared to the original formulation.
    • Pentane-1,5-diol demonstrated low risk for skin and eye irritation and low toxicity.

    Conclusions:

    • Pentane-1,5-diol is a versatile ingredient for dermatological preparations, enhancing API penetration and improving formulation aesthetics.
    • It offers a potentially safer and more effective alternative to traditional diols like propylene glycol.
    • Pentane-1,5-diol functions as an effective antimicrobial preservative and enhances product usability, leading to improved topical drug formulations.