Related Experiment Videos
In vivo multiple-mouse MRI at 7 Tesla.
Nicholas A Bock1, Brian J Nieman, Johnathan B Bishop
1Department of Medical Biophysics, University of Toronto, Toronto, Canada. nbock@sten.sunnybrook.utoronto.ca
Magnetic Resonance in Medicine
|October 11, 2005
Summary
This study introduces a novel multiple-mouse magnetic resonance imaging (MRI) technique. This method significantly enhances throughput for both live and fixed mouse imaging studies.
Area of Science:
- Biomedical Imaging
- Preclinical Research
- Magnetic Resonance Imaging
Background:
- High-throughput imaging is crucial for preclinical research.
- Current mouse MRI methods can be time-consuming.
- Advancements are needed to accelerate data acquisition.
Purpose of the Study:
- To develop a live, high-field multiple-mouse MRI method.
- To increase the throughput of mouse imaging studies.
- To validate the method's performance and image quality.
Main Methods:
- Utilized a 7 Tesla MRI scanner with multiple transmit and receive channels.
- Employed 7 shielded radiofrequency (RF) coils for concurrent imaging of live mouse brains.
- Used a 16 RF coil array for 3D imaging of fixed, contrast-perfused whole mouse bodies.
Main Results:
- Phantom experiments confirmed uniform signal-to-noise ratio and minimal ghost artifacts.
- High-quality, artifact-free 3D images of 7 live mouse brains at 156 micrometer isotropic resolution were acquired.
- High-quality, artifact-free 3D images of 16 fixed whole mice at 100 micrometer isotropic resolution were obtained.
Conclusions:
- The developed multiple-mouse MRI method significantly increases imaging throughput.
- This technique is effective for both live and fixed mouse studies.
- The throughput increase is proportional to the number of RF coils used.