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Updated: Aug 15, 2026
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
The effect of a nicorandil congener on isolated human myometrium
K Parimala1, Jacob Peedicayil, Abraham Peedicayil
1Department of Pharmacology, Christian Medical College, Vellore, India.
Objective:
To determine the effect of a nicorandil congener, SG-209 on the myometrium.
Study Design:
Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.0 and 10 microM). The mean height of contraction and the area under the curve were analysed using a non-parametric test.
Results:
At a 10 microM concentration, SG-209 significantly decreased the mean area under the curve from 10.8 to 2.5 cm2 (p<0.05).
Conclusion:
SG-209 significantly relaxes the human non-pregnant myometrium. Along with its congener, nicorandil, it may be useful in clinical conditions that require uterine relaxation.
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