Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Miliary tuberculosis involving the central nervous system.

T Carrada-Bravo1

  • 1Tropical Infectology Unit, Instituto Mexicano del Seguro Social, Hospital General de Zona y Medicina Familiar 2, Delegación de Guanajuato, Irapuato, Guanajuato, México. teocamx@yahoo.com.es

Neurologia (Barcelona, Spain)
|October 12, 2005
PubMed
Summary

Systemic lupus erythematosus (SLE) patients on prednisone may develop neuroinfection from Mycobacterium tuberculosis. Early diagnosis and treatment with anti-tuberculosis drugs are crucial for managing this severe complication.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Progressive human viral encephalitis associated to a bat bite].

Neurologia (Barcelona, Spain)·2006
Same author

Progressive multifocal leukoencephalopathy: clinical description and demonstration of the causal agent.

Neurologia (Barcelona, Spain)·2005
Same author

Update on sporotrichosis.

Australian family physician·1995
Same author

[The immunology of cholera and the molecular biology of cholera toxin. Recent progress and future perspectives].

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)·1994
Same author

[Coccidioidomycosis in children].

Boletin medico del Hospital Infantil de Mexico·1989
Same author

[Rabies as a public health problem].

Boletin medico del Hospital Infantil de Mexico·1989

Area of Science:

  • Neurology
  • Infectious Diseases
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
  • Corticosteroid therapy, like prednisone, is commonly used to manage SLE flares.
  • Immunosuppression increases susceptibility to opportunistic infections.

Observation:

  • A woman with SLE on prednisone developed acute febrile neuroinfection.
  • MRI revealed diffuse miliary micronodular lesions in the CNS and lungs.
  • Lumbar puncture showed pleocytosis, hypoglycorrhachia, elevated proteins, and acid-fast bacilli.

Findings:

  • Diagnosis confirmed: Mycobacterium tuberculosis infection of the central nervous system and lungs.
  • Treatment involved a four-drug anti-tuberculosis regimen (ethambutol, rifampin, isoniazid, pyrazinamide).

Related Experiment Videos

  • Initial treatment led to significant MRI improvement, though neurological deficits persisted.

    • Implications:

    • Highlights the risk of disseminated tuberculosis in immunosuppressed SLE patients.
    • Emphasizes the importance of considering tuberculosis in febrile neuroinfection among SLE patients.
    • Underscores the need for prompt diagnosis and aggressive multi-drug therapy for tuberculous neuroinfection.