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Central nervous system catecholamine content and norepinephrine release after AV3V ablation
1Department of Physiology and Biophysics, University of Tennessee, Memphis 38163.
The American Journal of Physiology
|June 1, 1992
Summary
Electrolytic ablation of the anteroventral third cerebral ventricle (AV3V-X) does not cause long-term brain catecholamine depletion. However, it enhances norepinephrine release in the paraventricular nucleus/anterior hypothalamus during hemorrhage.
Area of Science:
- Neuroscience
- Endocrinology
- Physiology
Background:
- Electrolytic ablation of the anteroventral third cerebral ventricle (AV3V-X) causes immediate changes in brain catecholamines.
- These acute effects include increased norepinephrine release and catecholamine depletion.
Purpose of the Study:
- To investigate if catecholamine depletion and altered norepinephrine release persist after AV3V-X.
- To assess long-term effects of AV3V-X on brain catecholamine levels and release during hemorrhage.
Main Methods:
- Rats underwent AV3V-X or sham surgery.
- Catecholamine concentrations and norepinephrine release in specific brain regions (P/A, DM) were measured 14-18 days post-surgery.
- Hemorrhage was induced to assess norepinephrine release.
Main Results:
- AV3V-X did not lead to chronic global catecholamine depletion.
- Epinephrine was decreased only in the midbrain; norepinephrine was increased only in the cortex.
- Hemorrhage-induced norepinephrine release was significantly higher in the paraventricular nucleus/anterior hypothalamus (P/A) of AV3V-X rats compared to controls.
Conclusions:
- AV3V-X does not result in persistent, widespread central nervous system catecholamine depletion.
- AV3V-X enhances norepinephrine release in the P/A during hemorrhage, suggesting altered neurochemical responses to stress.