Related Experiment Videos
Amebiasis complicating carcinomas: a diagnostic dilemma.
B R Mhlanga1, L O Lanoie, H J Norris
1Department of Pathology, Georgetown University School of Medicine, Washington, DC.
Summary
Entamoeba histolytica trophozoites can invade tumors, potentially delaying cancer diagnosis. A biopsy is crucial to rule out underlying carcinoma when amebiasis is suspected.
Area of Science:
- Pathology
- Infectious Diseases
- Oncology
Background:
- Cutaneous amebiasis can mimic squamous cell carcinoma.
- Carcinomas at various sites may be colonized by Entamoeba histolytica.
Observation:
- Trophozoites of Entamoeba histolytica were observed invading the surface and stroma of cervical, perineal, and sigmoid colon carcinomas.
- This invasion occurred in two Black African women and one Black American man.
Findings:
- Entamoeba histolytica colonization of tumors is less recognized than its mimicry of squamous cell carcinoma.
- Misdiagnosis of amebiasis without an underlying carcinoma can lead to unnecessary surgery.
- Diagnosing amebiasis in the presence of an unrecognized carcinoma delays critical cancer treatment.
Implications:
- A smear diagnosing cutaneous amebiasis necessitates a biopsy to exclude or confirm an underlying carcinoma.
- This highlights the importance of differentiating amebiasis from malignancy for appropriate patient management.
- Early detection of both amebiasis and carcinoma is vital for effective treatment and patient outcomes.