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Related Experiment Videos

Amebiasis complicating carcinomas: a diagnostic dilemma.

B R Mhlanga1, L O Lanoie, H J Norris

  • 1Department of Pathology, Georgetown University School of Medicine, Washington, DC.

The American Journal of Tropical Medicine and Hygiene
|June 1, 1992
PubMed
Summary

Entamoeba histolytica trophozoites can invade tumors, potentially delaying cancer diagnosis. A biopsy is crucial to rule out underlying carcinoma when amebiasis is suspected.

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Area of Science:

  • Pathology
  • Infectious Diseases
  • Oncology

Background:

  • Cutaneous amebiasis can mimic squamous cell carcinoma.
  • Carcinomas at various sites may be colonized by Entamoeba histolytica.

Observation:

  • Trophozoites of Entamoeba histolytica were observed invading the surface and stroma of cervical, perineal, and sigmoid colon carcinomas.
  • This invasion occurred in two Black African women and one Black American man.

Findings:

  • Entamoeba histolytica colonization of tumors is less recognized than its mimicry of squamous cell carcinoma.
  • Misdiagnosis of amebiasis without an underlying carcinoma can lead to unnecessary surgery.
  • Diagnosing amebiasis in the presence of an unrecognized carcinoma delays critical cancer treatment.

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Implications:

  • A smear diagnosing cutaneous amebiasis necessitates a biopsy to exclude or confirm an underlying carcinoma.
  • This highlights the importance of differentiating amebiasis from malignancy for appropriate patient management.
  • Early detection of both amebiasis and carcinoma is vital for effective treatment and patient outcomes.