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Updated: Aug 15, 2026

Dissolved Solute Sampling Across an Oxic-Anoxic Soil-Water Interface Using Microdialysis Profilers
Published on: March 24, 2023
Factors influencing low-molecular-weight solute clearance during hemodialysis
Zhongping Huang1, William R Clark, Dayong Gao
1Department of Mechanical Engineering, Widener University, Chester, Pennsylvania 19013, USA. zhuang@mail.widener.edu
Abstract:
The relationship between delivered urea Kt/V and survival has raised concerns in recent outcome trials in chronic dialysis patients. Nevertheless, measurement of delivered small solute clearance remains the most common approach to quantify therapy. The purpose of this review is to provide an overview of the numerous factors influencing small solute clearance during hemodialysis. Although the focus of the review is on the manner in which dialyzer characteristics influence small solute clearances, factors related to other aspects of the extracorporeal circuit and to the patient will also be discussed.
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