[Experience in treating advanced prostate cancer with bladder outlet obstruction]

Area of Science:

• Urology
• Oncology
• Surgical Innovation

Context:

• Increasing incidence of advanced prostate cancer necessitates improved treatment strategies.
• Bladder outlet obstruction significantly impacts quality of life in advanced prostate cancer patients.
• Current treatments for advanced prostate cancer with obstruction have limitations.

Purpose:

• To evaluate the efficacy and safety of transurethral electrovaporization of the prostate (TVP) combined with castration and antiandrogen therapy.
• To assess the impact of TVP on urinary symptoms, urine flow, and prostate-specific antigen (PSA) levels.
• To determine the suitability of this combined treatment for advanced prostate cancer patients with bladder outlet obstruction.

Summary:

• A study involving 80 advanced prostate cancer patients with bladder outlet obstruction utilized TVP alongside castration and antiandrogen therapy.
• All TVP procedures were successful, demonstrating significant improvements in International Prostatic Symptom Score (IPSS) and maximum urine flow rate (Qmax).
• Postoperative PSA levels and prostate volume were significantly reduced, indicating effective disease management.

Impact:

• TVP combined with castration and endocrine therapy offers a safe and effective treatment option for advanced prostate cancer.
• This therapeutic approach can significantly alleviate bladder outlet obstruction symptoms.
• Improved patient outcomes and quality of life are achievable with this treatment modality.