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Related Experiment Videos

Can neck size in elastase-induced aneurysms be controlled? A prospective study.

Yong Hong Ding¹, Daying Dai, Debra A Lewis

¹Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

AJNR. American Journal of Neuroradiology

|October 13, 2005

Summary

Adjusting balloon position in rabbit aneurysm models controls neck size. A higher balloon position resulted in significantly smaller neck diameters and widths, confirming previous findings.

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Area of Science:

Vascular biology and experimental models
Biomedical engineering and device development
Surgical techniques and interventional radiology

Background:

Previous retrospective study suggested balloon position influences elastase-induced aneurysm neck size.
This prospective study aimed to validate and confirm these earlier findings.

Purpose of the Study:

To prospectively investigate the effect of occlusion balloon position on the neck size of elastase-induced aneurysms in a rabbit model.
To confirm the controllability of aneurysm neck dimensions through procedural adjustments.

Main Methods:

Ninety rabbits underwent creation of elastase-induced aneurysms.
Two groups were established based on balloon position: low (Group 1) and high (Group 2).
Digital subtraction angiography was used for follow-up, with aneurysm dimensions measured and statistically analyzed.

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Main Results:

Group 1 (low balloon) showed significantly larger mean aneurysm neck diameter (3.4 mm vs 2.3 mm) and width (3.8 mm vs 3.3 mm) compared to Group 2 (high balloon).
The incidence of wide-necked aneurysms was significantly higher in Group 1 (29%) than in Group 2 (4%).
Mean dome-to-neck ratios were lower in Group 1 (1.2) versus Group 2 (1.7), indicating more favorable neck dimensions with higher balloon placement.

Conclusions:

The position of the occlusion balloon is a critical factor in controlling the neck size of elastase-induced aneurysm models.
Adjusting balloon placement offers a method to modulate aneurysm neck dimensions in experimental settings.