Resistance of Peptostreptococcus spp. to macrolides and lincosamides: inducible and constitutive phenotypes
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1Servicio de Microbiología, Hospital Ramón y Cajal, Instituto Nacional de la Salud, Madrid, Spain.
Abstract:
The activities of erythromycin and clindamycin against 350 Peptostreptococcus strains were studied during a 5-year period (1986 to 1991). In 5.1% of the Peptostreptococcus strains, which presented dissociated resistance (clindamycin MIC, less than or equal to 1 microgram/ml; erythromycin MIC, greater than 8 micrograms/ml), evidence of inducible macrolide-lincosamide resistance was shown. A total of 17.7% of the strains presented a constitutive phenotype; the clindamycin and erythromycin MICs for these strains were greater than 8 micrograms/ml.
Insights
Erythromycin and clindamycin resistance was studied in Peptostreptococcus strains. Inducible resistance was found in 5.1% of strains, while 17.7% showed constitutive resistance to these antibiotics.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Peptostreptococcus species are anaerobic bacteria implicated in various infections.
- Antibiotic resistance, particularly to macrolides and lincosamides, is a growing concern in clinical settings.
- Understanding resistance patterns is crucial for effective treatment strategies.
Purpose of the Study:
- To investigate the antimicrobial activity of erythromycin and clindamycin against Peptostreptococcus strains.
- To identify and characterize patterns of antibiotic resistance, including inducible and constitutive resistance phenotypes.
Main Methods:
- Susceptibility testing of 350 Peptostreptococcus strains against erythromycin and clindamycin.
- Determination of Minimum Inhibitory Concentrations (MICs) for both antibiotics.
- Phenotypic characterization of inducible and constitutive macrolide-lincosamide resistance.
Main Results:
- 5.1% of strains exhibited dissociated resistance, indicating inducible macrolide-lincosamide resistance (clindamycin MIC ≤ 1 µg/ml; erythromycin MIC > 8 µg/ml).
- 17.7% of strains displayed a constitutive resistance phenotype, with high MICs for both erythromycin and clindamycin (MICs > 8 µg/ml).
Conclusions:
- A significant proportion of Peptostreptococcus strains demonstrate resistance to erythromycin and clindamycin.
- The presence of both inducible and constitutive resistance mechanisms highlights the need for careful antibiotic selection.
- Monitoring antibiotic resistance in Peptostreptococcus is essential for guiding therapeutic choices.