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Related Experiment Videos

Fisher's microscope and Haldane's ellipse.

D Waxman1, J J Welch

  • 1Centre for the Study of Evolution, School of Life Sciences, University of Sussex, Brighton BN1 9QG, Sussex, United Kingdom. d.waxman@sussex.ac.uk

The American Naturalist
|October 15, 2005
PubMed
Summary

Fisher's geometrical model for adaptation is generalized by allowing selection intensity to vary across traits, addressing Haldane's concerns about independent trait contributions and potentially biasing mutation size outcomes.

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Area of Science:

  • Evolutionary biology
  • Population genetics

Background:

  • Fisher's geometrical model analyzes mutation size in adaptation.
  • Haldane questioned its generality due to simplified natural selection assumptions, particularly independent trait contributions to fitness.

Purpose of the Study:

  • To generalize Fisher's geometrical model by incorporating variable selection intensity across traits.
  • To investigate the impact of this generalization on adaptation dynamics and mutation size bias.

Main Methods:

  • Modified Fisher's geometrical model to allow for differing selection intensities per trait.
  • Introduced a single quantity representing the pre-adaptation phenotype.
  • Compared adaptation outcomes between the original and generalized models.

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Main Results:

  • Haldane's concerns are addressed by allowing variable selection intensity.
  • The generalization can be achieved using a single pre-adaptation phenotype descriptor.
  • The generalized model can bias adaptation towards larger or smaller mutations compared to the original model.

Conclusions:

  • The generalized model offers a more robust framework for studying adaptation.
  • Variable selection intensity is a crucial factor in mutation size effects during adaptation.
  • Re-evaluating the applicability of Fisher's original model is warranted.