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Updated: Aug 15, 2026

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy
Published on: January 12, 2022
Optical coherence tomography findings in tamoxifen retinopathy
Vincent Gualino1, Salomon Y Cohen, Marie-Noëlle Delyfer
1Department of Ophthalmology, Hôpital Lariboisiĕre, Assistance Publique-Hôpitaux de Paris, Université Paris #7, Paris, France.
Purpose:
To describe optical coherence tomography (OCT) findings in two cases of typical tamoxifen retinopathy.
Design:
Observational cases report.
Methods:
Two patients with tamoxifen retinopathy were imaged with fluorescein angiography and OCT 3.
Results:
Fluorescein angiography showed foveolar hyperfluorescence. OCT revealed a foveolar cystoid space with focal disruption of the photoreceptor line. There was no evidence of macular edema or thickening.
Conclusions:
In both cases, OCT findings are not consistent with previous descriptions of tamoxifen retinopathy, based on fundus examination and fluorescein angiography, which include a description of macular edema. This new imaging suggests that tamoxifen maculopathy may include a foveolar cystoid space different from macular edema.
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