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Updated: Aug 15, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
Published on: August 31, 2014
K65R and Y181C are less prevalent in HAART-experienced HIV-1 subtype A patients
Ravindra K Gupta1, Ian L Chrystie, Siobhan O'Shea
1Department of Infection, Guy's and St Thomas' NHS Foundation Trust (GSTT), London, UK.
Abstract:
The vast majority of HIV-1 infections globally are caused by subtype A or C, although little is known about their drug resistance profiles. We found that HAART-experienced patients infected with subtype A had a lower prevalence of K65R and Y181C than those with subtypes B or C, despite similar exposure to antiretroviral agents that select for these mutations. If confirmed, this information may be important in the planning of antiretroviral regimens in patients infected with HIV-1 subtype A.

