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Relationship between body composition and skeletal muscle eNOS.

R C Hickner1, G Kemeny, H W Stallings

  • 1Human Performance Laboratory, Department of Exercise and Sport Science, East Carolina University, Greenville, NC, USA. Hicknerr@mail.ecu.edu

International Journal of Obesity (2005)
|October 19, 2005
PubMed
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Overweight women have lower skeletal muscle endothelial nitric oxide synthase (eNOS) protein content and activity compared to lean women. This inverse relationship between eNOS and body fat may impact endothelial function and insulin sensitivity.

Area of Science:

  • Physiology
  • Cardiovascular Health
  • Metabolic Health

Background:

  • Endothelial dysfunction, insulin resistance, and cardiovascular disease are linked in overweight individuals.
  • Nitric oxide plays a crucial role in endothelial function.

Purpose of the Study:

  • To investigate if skeletal muscle endothelial nitric oxide synthase (eNOS) protein content and activity are lower in overweight women compared to lean women.

Main Methods:

  • Study 1: Muscle biopsy, body composition analysis (hydrostatic weighing), and peak aerobic capacity (indirect calorimetry) in 19 women.
  • Study 2: Determined eNOS activity in lean and overweight women, controlling for aerobic capacity.

Main Results:

  • Skeletal muscle eNOS content inversely correlated with percent body fat and BMI.

Related Experiment Videos

  • Total eNOS activity was significantly lower in overweight women compared to lean women.
  • Aerobic capacity did not independently predict skeletal muscle eNOS content.

    • Conclusions:

    • An inverse relationship exists between eNOS and percent body fat in women.
    • Reduced eNOS may contribute to endothelial dysfunction and insulin sensitivity issues in overweight women.