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[Correlation analysis between biochemical and biophysical markers of endothelium damage in children with diabetes

Barbara Głowińska-Olszewska1, Mirosława Urban, Joanna Tołwińska

  • 1II Klinika Chorób Dzieci AM w Białymstoku. bglowinska@poczta.onet.pl

Endokrynologia, Diabetologia I Choroby Przemiany Materii Wieku Rozwojowego : Organ Polskiego Towarzystwa Endokrynologow Dzieciecych
|October 20, 2005
PubMed

Insights

Children with type 1 diabetes show early signs of endothelial damage, including elevated adhesion molecules and impaired blood vessel function. These findings highlight the need for monitoring vascular health in pediatric diabetes patients.

Area of Science:

  • Cardiovascular Research
  • Pediatric Endocrinology
  • Vascular Biology

Background:

  • Endothelial damage is an early indicator of atherosclerosis.
  • Adhesion molecules serve as early markers for atherosclerotic disease.
  • Type 1 diabetes in children can impact vascular health.

Purpose of the Study:

  • To evaluate adhesion molecule levels in children with type 1 diabetes.
  • To assess endothelial function using flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NTGMD).
  • To measure carotid intima-media thickness (IMT) and correlate biochemical and biophysical markers of endothelial dysfunction.

Main Methods:

  • Studied 76 children and adolescents with type 1 diabetes and 33 healthy controls.
  • Measured serum levels of adhesion molecules (sICAM-1, sVCAM-1, sE-selectin, sP-selectin) using immunoenzymatic methods.
  • Assessed endothelial function via brachial artery FMD and NTGMD, and carotid artery IMT using ultrasonography.

Main Results:

  • Elevated levels of sICAM-1 and sE-selectin were observed in the diabetes group compared to controls.
  • Significantly impaired FMD and increased IMT were found in children with type 1 diabetes.
  • A negative correlation between sE-selectin and FMD, and a positive correlation between sE-selectin and IMT were identified.

Conclusions:

  • Children and adolescents with type 1 diabetes exhibit elevated adhesion molecules, indicating endothelial dysfunction.
  • Impaired brachial artery FMD and increased carotid IMT confirm biophysical evidence of vascular damage.
  • The study establishes correlations between specific adhesion molecules and markers of endothelial dysfunction in pediatric diabetes.
Abstract

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