[Importance of the interface position in thrombocytapheresis with the AS 104 cell separator]

In plateletpheresis with the Fresenius AS 104 the interface position influences the separation efficiency and the cell contamination of the platelet concentrate. The aim of the present study is to improve the purity of the platelet concentrate by changing the interface position. Increasing interface position results in rising separation efficiency and cell contamination. Alternating interface position gives the best result with significantly lower leukocyte contamination and only a slight decrease of separation efficiency. Nevertheless we prefer separations with variable interface position to reduce an immunisation of the recipient by white blood cells.