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Sildenafil effects on sexual function in asymptomatic volunteers: a controlled study
Ram Kamin1, Itzhak Ben Zion, Bella Chudakov
1Faculty of Health Sciences, Ben Gurion University of the Negev, Israel.
Journal of Sex & Marital Therapy
|October 20, 2005
Summary
Sildenafil use in young, healthy men showed minor effects on sexual quality and desire. These subtle impacts in asymptomatic individuals are difficult to measure, similar to antidepressants in non-depressed patients.
Area of Science:
- Urology
- Sexual Medicine
- Pharmacology
Background:
- Sildenafil is widely used for erectile dysfunction.
- Its effects on sexual parameters in healthy, asymptomatic young men are not well-established.
- Understanding these effects can provide insights into sexual function and medication impact.
Purpose of the Study:
- To investigate the effects of sildenafil on sexual quality, satisfaction, and desire in young, asymptomatic men.
- To compare sildenafil's impact against a placebo in a naturalistic setting.
Main Methods:
- A randomized, placebo-controlled, crossover study design was employed.
- Ten healthy men (22-34 years old) with regular sexual partners participated.
- Participants received 50 mg sildenafil or placebo for two 2-week periods, taken before sexual activity.
Main Results:
- Sildenafil demonstrated small, borderline statistically significant effects on sexual quality, satisfaction, and desire.
- The observed effects in this healthy cohort were subtle and challenging to quantify.
- Findings suggest that sildenafil's major effects are likely seen in individuals with clinical conditions, not in asymptomatic volunteers.
Conclusions:
- Sildenafil may have subtle effects on sexual experience in young, asymptomatic men.
- The impact is less pronounced than in men with erectile dysfunction.
- Further research is needed to fully elucidate the nuanced effects of sildenafil in diverse populations.